Optimizing cell proliferation and function for immunotherapy with recombinant growth factors and cytokines

Cell & Gene Therapy Insights 2022; 8(8), 1035–1043

DOI: 10.18609/cgti.2022.153

Published: 18 September 2022
Innovator Insight
Martin Keough

As more and new immune cell therapies continue to be developed, the demand for Animal Component-Free (ACF) and GMP-quality recombinant human growth factors and cytokines has increased. Cytokine therapies have become extremely popular due to their effectiveness in the treatment of cancer and autoimmune conditions.The use of GMP products is the gold standard for Cell & Gene therapy manufacturing. Especially the use of GMP recombinant human interleukins as companies prepare for clinical trials or scale-up manufacturing of their immune cell therapies. Interleukins (ILs) are a group of cytokines that regulate immune and inflammatory responses. Interleukins also regulate cell growth, differentiation, and motility. The discovery of Interleukin (IL-2) as a “T-cell growth factor” (TCGF) in 1976 revolutionized the fields of basic immunology research and immunotherapy for human cancers.