BioInsights - Vector bioprocessing & raw materials - spotlight

CELL & GENE THERAPY INSIGHTS

Andrew D. Tustian

Guest Editor:

Andrew D. Tustian, Senior Director, Preclinical Manufacturing and Process Development at Regeneron Pharmaceuticals

April 2023

Vector bioprocessing & raw materials

Webinars

The fast and the curious – optimized development of high performing AAV vectors

The fast and the curious – optimized development of high performing AAV vectors

Dirk Grimm, David Schaffer

Advancing the purification of VSV-G pseudotyped lentiviral vectors by using affinity chromatography

Advancing the purification of VSV-G pseudotyped lentiviral vectors by using affinity chromatography

Pim Hermans, Frank Detmers

Case studies: Successful scale-up of upstream viral vector processes using adherent and suspension platforms

Case studies: Successful scale-up of upstream viral vector processes using adherent and suspension platforms

Samir Acharya, Denis Kole

Navigating evolving regulatory CMC guidance in the AAV gene therapy field

Navigating evolving regulatory CMC guidance in the AAV gene therapy field

Y Zhi, C Bec, M Brewer et al.

Emerging trends and challenges in AAV manufacturing for gene therapies

Emerging trends and challenges in AAV manufacturing for gene therapies

M Fuller, T Patel, I Eugenis

Scalable production in single-use bioreactors

Scalable production in single-use bioreactors

Jonathan Zmuda, Premkumar Jayaraman

Chromatographic modalities, buffer selection and other considerations for enrichment of AAV product

Chromatographic modalities, buffer selection and other considerations for enrichment of AAV product

Rok Žigon

De-risking lentiviral vector production using a robust, scalable, suspension-based platform

De-risking lentiviral vector production using a robust, scalable, suspension-based platform

Skip the hassle for AAV and AdV empty/full and titer data with Stunner

Skip the hassle for AAV and AdV empty/full and titer data with Stunner

Nelis Denys

Development of anti-AAV assay for detection of pre-existing AAV immunity

Development of anti-AAV assay for detection of pre-existing AAV immunity

Zhe Liu, John Chappell

High-throughput process & analytical platforms to accelerate gene therapy scale-up

High-throughput process & analytical platforms to accelerate gene therapy scale-up

P Starremans, K Warrington, N Jesuraj