Jul
29
2021
On demand

Accelerating CAR-T process development: The power of process insight

As gene-modified cell therapies advance to address new indications, the need for rapid development of robust manufacturing processes becomes increasingly important. Process optimization sets the stage for clinical and commercial manufacturing and plays a foundational role in decreasing time to market and lowering costs of goods (COGs).

This series of case studies presents Design of Experiments (DOE)-driven development of process knowledge and rapid optimization of T-cell expansion in a miniaturized, automated multi-parallel setup as well as the phenotypic analysis of CAR-T cells with donor clustering.

  • Accelerating media screening and critical process parameters (CPP) identification and optimization
  • Profiling CAR-T cells and donor clustering
  • Decreasing development time and COGs

Julia Hupfeld, Ph.D.

Advanced Therapies Expert, Sartorius

Julia Hupfeld has several years of experience in process development for cell-based therapeutics (ATMPs) and also worked on expansion and modulation of human mesenchymal stem cells on biomaterials in bioreactors during her Ph.D. studies at Roche. Julia holds a Ph.D. from the Technical University of Munich and an M.Sc. in Molecular Biotechnology from the University of Heidelberg and B.Sc. in Molecular Medicine from the University of Goettingen.

SPEAKERS

Julia Hupfeld, Ph.D.
Advanced Therapies Expert, Sartorius

You might also like

Thinking translational: Things to consider in CAR T cell research workflows

S Rösch, PhD
Saskia Rösch, PhD
Saskia Rösch, PhD
Global Product Manager at Miltenyi Biotec
22 Jun 2022
36
Days
7
Hrs
18
Min
Register

Monitoring of circulating CAR T cells

A Graband,
D Hünecke,
D Bremm
Annika Graband
Annika Graband
Product Manager, Cell Analysis Reagents at Miltenyi Biotec
Dr. Sabine Hünecke
Dr. Sabine Hünecke
Head of Laboratory, Stem Cell Transplantation and Immunotherapy at University Hospital Frankfurt
Dr. Melanie Bremm
Dr. Melanie Bremm
Deputy Head of Laboratory, Stem Cell Transplantation and Immunotherapy at University Hospital Frankfurt
31 May 2022
14
Days
7
Hrs
18
Min
Register

Improving T cell therapy manufacturing processes with automation and...

E Zynda, PhD
Evan Zynda, PhD
Evan Zynda, PhD
Staff Scientist, Cell Biology at Thermo Fisher Scientific
26 May 2022
9
Days
7
Hrs
18
Min
Register

Streamlined workflow solutions for cell and gene therapy analytics

A Graband
Annika Graband
Annika Graband
Product Manager, Cell Analysis Reagents at Miltenyi Biotec
24 May 2022
7
Days
7
Hrs
18
Min
Register

Strategic partnering to enable cell therapy commercialization

J Smith
X de Mollerat du Jeu
Jenessa Smith
Jenessa Smith
Associate Director of Process Development at ArsenalBio
Xavier de Mollerat du Jeu
Xavier de Mollerat du Jeu
Senior Director, R&D, Cell and Gene Therapy at Thermo Fisher Scientific
12 May 2022
Watch now