Cell and gene therapy matures: Streamlining and smoothing the path to commercialization
Jan
11
2022
On demand

Cell and gene therapy matures: Streamlining and smoothing the path to commercialization

Tuesday 08:00 PST / 11:00 EST / 16:00 GMT / 17:00 CET
Sponsor
Cell and gene therapy matures: Streamlining and smoothing the path to commercialization

The cell and gene therapy (CGT) industry is coming of age with multiple approved products in both AAV and gene-modified cell therapy. As the field continues to grow and mature, the advantages of integrated products and solutions for therapeutic developers is becoming apparent. Typically CGT program development requires managing multiple relationships and this presents challenges in aligning timelines. In this talk learn how Charles River's portfolio of products and services helps to enable our partners to streamline their path to commercialization.

  • Snapshot of Charles River’s CGT development portfolio
  • An in-depth look at early activities including antibody generation and target screening (basal activity, on-target/off-target binding)
  • Cell supply considerations for autologous and allogeneic programs
  • Plasmid, vector, and cell therapy manufacturing overview
Matt Hewitt PhD
Matt Hewitt PhD
Senior Director, Scientific Services, Cell and Gene Therapy, Charles River Laboratories

Matthew Hewitt is currently the Head of Clinical Development for the Personalized Medicine (PerMed) Initiative within Lonza. The PerMed Initiative has a cell and gene therapy focus working to alleviate pain-points in commercializing cell therapies. One of Matt’s responsibilities is the Cocoon Platform, a closed, automated, scalable cell therapy manufacturing platform which relieves many cell therapy manufacturing difficulties.

Prior to joining Lonza, Matt led the Tumor Immunology and Microenvironment program at Bellicum Pharmaceuticals which concentrated on improving cell therapy efficacy in solid tumors. Matt led the Immunology group at the University of Pennsylvania’s Gene Therapy Program under Dr. James Wilson managing numerous AAV gene therapy programs. Matt received his Ph.D. in Biophysics & Physiology from the University of Alabama at Birmingham and completed his post-doctoral fellowship at Johns Hopkins University.