Manufacturing of RCA-free adenoviral vectors
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Adenoviral vectors are frequently used as delivery tools for vaccines and gene therapy applications. In most cases, replication-incompetent adenoviruses (RCA) are employed, which, once they have infected a target cell, cannot spread further in a patient‘s body. In such applications, regulatory guidelines require that the formation of RCA during the production process must be minimized. Since the risk of RCA occurrence depends on the adenoviral vector and the cell line used for virus stock generation and manufacturing, the choice of an appropriate cell line and production platform is a critical decision. Ideally, it should allow, among other things, simple, scalable and GMP-compliant production of adenoviral vectors at high titers and without the risk of RCA formation.
Here we present the CAP® Ad platform, a production platform for adenoviral vectors based on CAP® cells and specifically designed to address these requirements. CAP® cells can be cultivated in all common bioreactors using serum-free, chemically defined media. They grow to high densities as single cells in suspension and support high titer, RCA-free adenoviral vector production. The webinar will provide further background information on the CAP® Ad production platform and typical process flows used for adenoviral vector manufacturing at industrial scale.
- Impact of the adenovirus biology on its use as a viral vector
- Uses of adenoviral vectors for various medical applications
- Importance of avoiding RCA in the manufacturing process
- Achieving industrial scale adenoviral vector production using the CAP® Ad platform
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