Automated and scalable closed-system platform for cell isolation and activation
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The cell therapy field is experiencing rapid growth with several treatments receiving recent regulatory approval and several therapies currently in clinical testing. Thermo Fisher Scientific has a line of Gibco™ CTS™ cell therapy devices developed to function as either a stand-alone system or integrated into a workflow that can help with the maintenance of critical quality attributes during manufacturing scale-up.
As a part of this workflow, the Gibco™ CTS™ DynaCellect™ Magnetic Separation System and single-use kits have been designed for scalable and robust cell processing with the CTS Dynabeads™ platform. The instrument utilizes an integrated magnet-rocker and a fluidics panel for target cell separation and subsequent bead removal in a closed system.
Using the Gibco™ CTS™ DynaCellect™ Cell Isolation Kit with CTS Dynabeads, we consistently achieve >85% isolation efficiency of target cells with >95% purity with no effect on cell viability. Furthermore, automated bead removal using the Gibco™ CTS™ DynaCellect Bead Removal Kit resulted in >85% target cell recovery.
DynaCellect is highly scalable allowing up to 1 L of reaction volume for cell isolation with throughput time of ~100 minutes. Similarly, bead removal is achieved through a continuous flow over the rocker-magnet to ensure rapid processing of volumes suitable for autologous and allogenic workflows. while providing, automation, modularity, flexibility, and scalability of cell therapy manufacturing.
- The importance of a scalable and robust cell isolation and bead removal in a closed, automated instrument
- How to achieve >90% isolation efficiency of target cells with >95% purity with no effect on cell viability
- The benefit of avoiding manual processing during cell therapy manufacturing, which can result in inconsistencies, contamination, and long throughput times
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