Life on a chip - vascularized micro-tumor chips for mimicking clinical drug responses

Sponsor

In this webinar, you will learn about cutting-edge organ chip technology already in use by several of the top pharmaceutical companies for drug development and immuno-oncology applications. Most cells in our body are no farther from a blood vessel than the width of a hair. Blood vessels help pattern tissues and provide them with their nutrients, and since almost all therapeutics — whether small molecules, antibodies, or leukocytes — reach our tissues via blood vessels, no model of tissue-drug interaction is realistic without this supporting vascular network. You will learn what readouts are available in vitro for developing drug, cell and gene-based therapies, including:

Continual imaging of tumor growth and response to drugs
Imaging of leukocyte vascular adhesion & extravasation
Assessment of tumor occupancy and killing by leukocytes, including CAR-Ts
Assessment of monoclonal antibody & bispecific delivery and efficacy
Assessment of target gene expression by in situ staining or qPCR
Collection of venous outflow for assessment of biomarkers

Attend this webinar to learn:

How responses in Vascularized Micro-Tumor chips compare to responses seen in patient tumors
What types of drug, cell-based and gene therapy studies can be conducted using Vascularized-Micro Tumor chips
How Vascularized Micro-Tumor chips compare to other models, such as 2D cell culture or spheroid models

Dr Chris Hughes

CSO, Aracari Biosciences

Dr. Hughes is a professor in the Departments of Molecular Biology & Biochemistry and Biomedical Engineering at UC Irvine. His recent appointments have included Department Chair, Director of the Edwards Lifesciences Center for Advanced Cardiovascular Technology, and co-director of the Onco-Imaging and Biotechnology (OIB) Program, part of the Chao Family Comprehensive Cancer Center at UCI. The work in his lab spans multiple scales – from understanding the basic molecular mechanisms of angiogenesis (the growth of new blood vessels), to engineering of artificial tissues. Recently his lab has been pioneering “Body-on-Chip” technology, which allows for human micro-organs – heart, pancreas, tumor, etc. – to be grown in the lab with their own blood vessel network.

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