Vol 8 Issue 8

CELL AND GENE THERAPY INSIGHTS

September 2022 Issue

Vol 8 Issue 8

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Featuring

Issue Spotlight: Cell and gene therapy manufacturing scale-up/ scale-out
Other articles
Webinars

SPOTLIGHT

Cell and gene therapy manufacturing scale-up/ scale-out
Nolan Sutherland
Guest Editor:
Nolan Sutherland, Senior Scientist at Ring Therapeutics

Editorial

De-risking late-stage activities by retaining your early-stage expertise

De-risking late-stage activities by retaining your early-stage expertise

Nolan Sutherland
28 August 2022
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Expert Insight

Stabilizing DNA–PEI complexes improves scalability of suspension lentiviral viral vector and AAV processes

Stabilizing DNA–PEI complexes improves scalability of suspension lentiviral viral vector and AAV processes

B Olden, H Seo, R Barnes et al.
28 August 2022
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Innovator Insight

Manufacturing NK cells for the clinic: the Spanish experience

Manufacturing NK cells for the clinic: the Spanish experience

Antonio Pérez-Martínez, Marty Giedlin, Mariam Ammari
14 December 2022
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Process development optimization for GMP manufacturing: a CAR-T case study

Process development optimization for GMP manufacturing: a CAR-T case study

Gary M Pigeau
12 December 2022
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Achieve significantly increased adenovirus yield with density gradient ultracentrifugation: a comparative study

Achieve significantly increased adenovirus yield with density gradient ultracentrifugation: a comparative study

Shawn Sternisha
19 October 2022
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Optimizing cell proliferation and function for immunotherapy with recombinant growth factors and cytokines

Optimizing cell proliferation and function for immunotherapy with recombinant growth factors and cytokines

Martin Keough
18 September 2022
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Accelerating cell therapy discovery & development with non-viral gene engineering

Accelerating cell therapy discovery & development with non-viral gene engineering

Xiaobai Patrinostro, David Hermanson, Scott Silaika
12 September 2022
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Optimizing E. coli cell growth performance with in-line, real-time OD600 (abs/mm) monitoring during the fermentation process

Optimizing E. coli cell growth performance with in-line, real-time OD600 (abs/mm) monitoring during the fermentation process

Tanja Buch, Ramsey Shanbaky
25 August 2022
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Interview

De-risk & accelerate the drug development process for gene therapy

De-risk & accelerate the drug development process for gene therapy

Kim Watanabe
22 September 2022
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Making the switch from autologous to allogeneic cell therapy

Making the switch from autologous to allogeneic cell therapy

Elena Matsa, Andy Holt
11 September 2022
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Collaboration, technology & innovation in the scale-up of viral vector manufacturing

Collaboration, technology & innovation in the scale-up of viral vector manufacturing

Matthias Hebben
2 September 2022
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Mentoring new talent in the cell and gene therapy manufacturing sphere

Mentoring new talent in the cell and gene therapy manufacturing sphere

Angela Collura
2 September 2022
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Beginning with the end in mind: how early plasmid design and CDMO partnership can set you up for success in cell or gene therapy manufacturing

Beginning with the end in mind: how early plasmid design and CDMO partnership can set you up for success in cell or gene therapy manufacturing

Richard Parker-Manuel, Qian Liu
31 August 2022
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FastFacts

Off-the-shelf lentiviral vector packaging plasmids

Off-the-shelf lentiviral vector packaging plasmids

2 April 2023
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Tailor your cell culture platform to achieve your research objectives & scale requirements

Tailor your cell culture platform to achieve your research objectives & scale requirements

4 November 2022
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Alleviate crucial challenges in scaling up gene therapy manufacturing

Alleviate crucial challenges in scaling up gene therapy manufacturing

Emily Moran
11 September 2022
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Key benefits of a microfluidic platform for cell culture at a clinically relevant scale

Key benefits of a microfluidic platform for cell culture at a clinically relevant scale

James Kusena, Mohsen Shaeri, Pedro Costa
10 September 2022
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Digital data transformation: optimizing CGT processes and accelerating scale-up & tech transfer for manufacturing success

Digital data transformation: optimizing CGT processes and accelerating scale-up & tech transfer for manufacturing success

Teodor Leahu
8 September 2022
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Poster

Successful suspension-based viral vector manufacturing scale-up from process development to clinic

Successful suspension-based viral vector manufacturing scale-up from process development to clinic

D Kole, T P Cripe, L Giannunzio et al.
7 December 2022
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De-risk and accelerate the drug development process for gene therapy

De-risk and accelerate the drug development process for gene therapy

Kim Watanabe
29 September 2022
Read

Journal articles

Innovator Insight

Evaluating DNA purity ratio determination with the CTech<sup>™️</sup> SoloVPE<sup>®️</sup> System

Evaluating DNA purity ratio determination with the CTech™️ SoloVPE®️ System

Nigel Herbert, Drusha Purohit, Hannah Mignault
2 September 2022
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Interview

Innovation in analytical tool development across the mRNA vaccine & AAV gene therapy spaces

Innovation in analytical tool development across the mRNA vaccine & AAV gene therapy spaces

Lawrence Thompson
21 September 2022
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Podcast

Insights into the editing of the human genome: where can novel non-viral polymeric delivery agents take us

Insights into the editing of the human genome: where can novel non-viral polymeric delivery agents take us

Tom Foti, Kris Saha
30 August 2022
Listen
Learning from pediatric CAR-T development: insights from manufacturing unique patient doses

Learning from pediatric CAR-T development: insights from manufacturing unique patient doses

Chris Brown
22 September 2022
Listen

FastFacts

A closed, modular approach to autologous CAR T cell therapy manufacturing

A closed, modular approach to autologous CAR T cell therapy manufacturing

Jason Isaacson
13 September 2022
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Automated and scalable closed-system platform for cell isolation and activation

Automated and scalable closed-system platform for cell isolation and activation

Tom Mellody
5 October 2022
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Robust quantitation of residual host cell and plasmid DNA & oncogenic fragments in HEK-based viral vector manufacturing

Robust quantitation of residual host cell and plasmid DNA & oncogenic fragments in HEK-based viral vector manufacturing

16 October 2022
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Poster

Scaling non-viral cell therapy approaches for solid tumor treatments

Scaling non-viral cell therapy approaches for solid tumor treatments

31 August 2022
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Webinars